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Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems to Facilitate Neurotherapeutic Discovery (R61/R33 Clinical Trial Not Allowed)

National Institutes of Health

PAR-25-060

HHS-NIH11

General Information

$750,000

Est. Program Funding:

October 20, 2027

Closing Date:

Expected No. of Awards

$750,000

Award Ceiling

Opportunity Number:
PAR-25-060

Owning Agency:
HHS-NIH11

Opportunity Category:
Discretionary (D)

Synopsis

This funding opportunity announcement (FOA) encourages the development and validation of animal models and human/animal tissue ex vivo systems that recapitulate the phenotypic and physiologic characteristics of a defined neurological or neuromuscular disorder. The goal of this FOA is to promote a significant improvement in the translational relevance of animal models or ex vivo systems that will be utilized to facilitate future development of neurotherapeutics. Ideally, models proposed for this FOA would have the potential to provide feasible and meaningful assessments of efficacy following therapeutic intervention that would be applicable in both preclinical and clinical settings. This FOA is part of a suite of Innovation Grants to Nurture Initial Translational Efforts (IGNITE) Program focused on enabling the exploratory and early stages of drug discovery.

Response Date	Oct 20, 2027 12:00:00 AM EDT
Posting Date	Oct 22, 2024 12:00:00 AM EDT
Archive Date	Nov 25, 2027 12:00:00 AM EST
Award Ceiling	750,000
Award Floor
Cost Sharing	No

Eligibility

Eligible Applicants

Others (see text field entitled "Additional Information on Eligibility" for clarification), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Public and State controlled institutions of higher education, Native American tribal organizations (other than Federally recognized tribal governments), Native American tribal governments (Federally recognized), Small businesses, City or township governments, Independent school districts, State governments, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Special district governments, For profit organizations other than small businesses, Public housing authorities/Indian housing authorities, County governments

Additional Info on Eligibility:

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name	National Institutes of Health
Link to Additional Information:	https://grants.nih.gov/grants/guide/pa-files/PAR-25-060.html
Grantor Contact Information:	If you have difficulty accessing the full announcement electronically, please contact: GrantSolutions Help Desk Phone: 301-402-2541

CFDA Program(s)

93.853: Extramural Research Programs in the Neurosciences and Neurological Disorders
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