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Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (R01 Clinical Trial Optional)

National Institutes of Health

PAR-25-036

HHS-NIH11

General Information

Est. Program Funding:

May 7, 2026

Closing Date:

Expected No. of Awards

Award Ceiling

Opportunity Number:
PAR-25-036

Owning Agency:
HHS-NIH11

Opportunity Category:
Discretionary (D)

Synopsis

This Notice of Funding Opportunity (NOFO) invites research grant applications that propose the development and evaluation of novel radioligands for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging in human brain and the incorporation of, pilot or clinical feasibility evaluation from previously collected data in pre-clinical studies. These studies are expected to provide the requisite data needed to advance promising PET ligands for use in clinical research.

Response Date	May 07, 2026 12:00:00 AM EDT
Posting Date	Nov 06, 2024 12:00:00 AM EST
Archive Date	Jun 12, 2026 12:00:00 AM EDT
Award Ceiling
Award Floor
Cost Sharing	No

Eligibility

Eligible Applicants

Public and State controlled institutions of higher education, Independent school districts, Native American tribal governments (Federally recognized), Private institutions of higher education, For profit organizations other than small businesses, Small businesses, County governments, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, City or township governments, State governments, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Others (see text field entitled "Additional Information on Eligibility" for clarification), Public housing authorities/Indian housing authorities, Special district governments

Additional Info on Eligibility:

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name	National Institutes of Health
Link to Additional Information:	https://grants.nih.gov/grants/guide/pa-files/PAR-25-036.html
Grantor Contact Information:	If you have difficulty accessing the full announcement electronically, please contact: GrantSolutions Help Desk Phone: 301-402-2541

CFDA Program(s)

93.242: Mental Health Research Grants
93.866: Aging Research
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