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Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R01 Clinical Trial Optional)

National Institutes of Health

PAR-25-069

HHS-NIH11

General Information

Est. Program Funding:

January 7, 2027

Closing Date:

Expected No. of Awards

Award Ceiling

Opportunity Number:
PAR-25-069

Owning Agency:
HHS-NIH11

Opportunity Category:
Discretionary (D)

Synopsis

The goal of the proposed funding announcement is twofold, to promote preclinical and patient based studies examining the mechanism(s) through which incretin mimetics (including agonists or antagonists of GLP-1, GIP-1, or dual GLP-1/GIP-1 agents) impact cancer risk, and to draw talented scientists who understand the dynamic changes caused by these agents to investigate the mechanisms of how these agents influence cancer risk rather than shorter term outcomes such as weight loss and diabetes. The data thus far suggests that these agents may increase the risk of some, while decreasing the risk of other obesity related cancers.

Response Date	Jan 07, 2027 12:00:00 AM EST
Posting Date	Nov 18, 2024 12:00:00 AM EST
Archive Date	Feb 12, 2027 12:00:00 AM EST
Award Ceiling
Award Floor
Cost Sharing	No

Eligibility

Eligible Applicants

Private institutions of higher education, Small businesses, Special district governments, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, State governments, County governments, Independent school districts, Native American tribal governments (Federally recognized), Others (see text field entitled "Additional Information on Eligibility" for clarification), Public and State controlled institutions of higher education, For profit organizations other than small businesses, Native American tribal organizations (other than Federally recognized tribal governments), Public housing authorities/Indian housing authorities, City or township governments, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education

Additional Info on Eligibility:

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name	National Institutes of Health
Link to Additional Information:	https://grants.nih.gov/grants/guide/pa-files/PAR-25-069.html
Grantor Contact Information:	If you have difficulty accessing the full announcement electronically, please contact: GrantSolutions Help Desk Phone: 301-402-2541

CFDA Program(s)

93.393: Cancer Cause and Prevention Research
:

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