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BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)

National Institutes of Health

RFA-DA-27-004

HHS-NIH11

General Information

Est. Program Funding:

November 8, 2027

Closing Date:

Expected No. of Awards

Award Ceiling

Opportunity Number:
RFA-DA-27-004

Owning Agency:
HHS-NIH11

Opportunity Category:
Discretionary (D)

Synopsis

The Theories, Models and Methods (TMM) initiative will support the development of computational tools for understanding dynamic brain circuits that are made broadly accessible to the greater research community. This program supports applications focused on tool building and dissemination in the domain of theories about neural circuit mechanisms, models of circuit structure and function, and/or computational methods of analysis spanning across scales from neurons to behavior. The development of novel theories, computational models and methods for understanding brain function will help characterize fundamental principles of brain function and organization, characterize cellular and circuit-level neural computations over time in different regions, and understand how interactions of multiple brain circuits enable flexible behaviors and contribute to brain-wide neural dynamics. These tools will be critical for developing treatments such as closed loop systems for brain disorders including Parkinsons disease and major depressive disorder.

Response Date	Nov 08, 2027 12:00:00 AM EST
Posting Date	Sep 16, 2025 12:00:00 AM EDT
Archive Date	Dec 14, 2027 12:00:00 AM EST
Award Ceiling
Award Floor
Cost Sharing	No

Eligibility

Eligible Applicants

Private institutions of higher education, State governments, For profit organizations other than small businesses, Public and State controlled institutions of higher education, Others (see text field entitled "Additional Information on Eligibility" for clarification), Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Native American tribal organizations (other than Federally recognized tribal governments), City or township governments, Independent school districts, Special district governments, County governments, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Small businesses

Additional Info on Eligibility:

Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.

Additional Information

Agency Name	National Institutes of Health
Link to Additional Information:	https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-27-004.html
Grantor Contact Information:	If you have difficulty accessing the full announcement electronically, please contact: GrantSolutions Help Desk Phone: 301-402-2541

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