This is a Notice of Funding Opportunity (NOFO) for a Single Source that invites a recipient organization funded under the Electronic Medical Records and Genomics (eMERGE): Genomic Risk Assessment and Management Network Coordinating Center (RFA-HG-19-015) to participate in the Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application will be peer-reviewed, and only meritorious applications will be considered.The NHGRI is announcing its intent to issue a single source cooperative agreement award to Vanderbilt University Medical Center to continue coordination of the eMERGE Risk Assessment Network. The eMERGE Network will extend through April 2030 follow-up and collection of outcome data on the roughly 25,000 patients receiving genomically informed risk assessment (GIRA) and management recommendations.