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Total Dollar Available
$ 100 Trillion

Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Optional)

Deadline: January 7, 2028

Opportunity Number: PAR-25-321

Agency: National Institutes of Health

Open Date: December 10, 2024

Close Date: January 7, 2028

Status: Posted

CFDA Numbers: 93.394, 93.395, 93.393, 93.399, 93.396

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BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed)

Deadline: June 15, 2026

Opportunity Number: RFA-EY-25-001

Agency: National Institutes of Health

Open Date: December 9, 2024

Close Date: June 15, 2026

Status: Posted

CFDA Numbers: 93.173, 93.286, 93.213, 93.865, 93.866, 93.853, 93.867, 93.273, 93.242, 93.279

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Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed)

Deadline: November 2, 2026

Opportunity Number: PAR-24-280

Agency: National Institutes of Health

Open Date: December 9, 2024

Close Date: November 2, 2026

Status: Posted

CFDA Numbers: 93.846

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Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required)

Deadline: November 2, 2026

Opportunity Number: PAR-24-279

Agency: National Institutes of Health

Open Date: December 9, 2024

Close Date: November 2, 2026

Status: Posted

CFDA Numbers: 93.846

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NIAMS Clinical Trial Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

Deadline: March 4, 2027

Opportunity Number: PAR-25-141

Agency: National Institutes of Health

Open Date: December 9, 2024

Close Date: March 4, 2027

Status: Posted

CFDA Numbers: 93.846

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Interventions to Reduce Sleep Health Disparities (R01 - Clinical Trials Optional)

Deadline: September 7, 2027

Opportunity Number: PAR-24-330

Agency: National Institutes of Health

Open Date: December 6, 2024

Close Date: September 7, 2027

Status: Posted

CFDA Numbers: 93.838, 93.839, 93.273, 93.866, 93.853, 93.361, 93.399, 93.837, 93.840, 93.233, 93.307

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Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional)

Deadline: May 7, 2027

Opportunity Number: PAR-25-100

Agency: National Institutes of Health

Open Date: December 6, 2024

Close Date: May 7, 2027

Status: Posted

CFDA Numbers: 93.279

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Preclinical Proof of Concept Studies for Rare Diseases (R21 Clinical Trial Not Allowed)

Deadline: June 2, 2026

Opportunity Number: RFA-TR-25-002

Agency: National Institutes of Health

Open Date: December 6, 2024

Close Date: June 2, 2026

Status: Posted

CFDA Numbers: 93.350

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Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed)

Deadline: December 3, 2027

Opportunity Number: RFA-DA-26-055

Agency: National Institutes of Health

Open Date: December 5, 2024

Close Date: December 3, 2027

Status: Posted

CFDA Numbers: 93.273, 93.279

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Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed)

Deadline: December 3, 2027

Opportunity Number: RFA-DA-26-056

Agency: National Institutes of Health

Open Date: December 5, 2024

Close Date: December 3, 2027

Status: Posted

CFDA Numbers: 93.273, 93.279

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Interventions to Address Disparities in Liver Diseases and Liver Cancer (R01 - Clinical Trials Optional)

Deadline: January 7, 2028

Opportunity Number: PAR-25-299

Agency: National Institutes of Health

Open Date: December 5, 2024

Close Date: January 7, 2028

Status: Posted

CFDA Numbers: 93.273, 93.307, 93.399

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NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R33 CT Required)

Deadline: January 7, 2027

Opportunity Number: PAR-25-025

Agency: National Institutes of Health

Open Date: December 5, 2024

Close Date: January 7, 2027

Status: Posted

CFDA Numbers: 93.838, 93.839, 93.233, 93.837

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NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R61/R33 Clinical Trial Required)

Deadline: January 7, 2027

Opportunity Number: PAR-25-026

Agency: National Institutes of Health

Open Date: December 5, 2024

Close Date: January 7, 2027

Status: Posted

CFDA Numbers: 93.840, 93.233, 93.839, 93.837, 93.838

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NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)

Deadline: May 7, 2026

Opportunity Number: PAR-25-239

Agency: National Institutes of Health

Open Date: December 5, 2024

Close Date: May 7, 2026

Status: Posted

CFDA Numbers: 93.121

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Alzheimer's Drug-Development Program (U01 Clinical Trial Optional)

Deadline: November 5, 2027

Opportunity Number: PAR-25-297

Agency: National Institutes of Health

Open Date: December 4, 2024

Close Date: November 5, 2027

Status: Posted

CFDA Numbers: 93.866

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Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21/R33 - Clinical Trial Optional)

Deadline: March 20, 2026

Opportunity Number: PAR-25-242

Agency: National Institutes of Health

Open Date: December 4, 2024

Close Date: March 20, 2026

Status: Posted

CFDA Numbers: 93.313, 93.173, 93.865, 93.989, 93.242, 93.399, 93.853, 93.286, 93.867

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Accelerating Solutions to Improve Access and Quality of Empirically-Supported Practices for Youth Mental Health (R01 Clinical Trial Optional)

Deadline: January 7, 2027

Opportunity Number: PAR-25-310

Agency: National Institutes of Health

Open Date: December 3, 2024

Close Date: January 7, 2027

Status: Posted

CFDA Numbers: 93.242

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NIAID Career Transition Award (K22 Independent Clinical Trial Not Allowed)

Deadline: January 7, 2028

Opportunity Number: PAR-25-251

Agency: National Institutes of Health

Open Date: December 3, 2024

Close Date: January 7, 2028

Status: Posted

CFDA Numbers: 93.855

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Career Transition Award for NINDS Intramural Clinician-Scientists (K22 Clinical Trial Not Allowed)

Deadline: November 12, 2027

Opportunity Number: PAR-25-215

Agency: National Institutes of Health

Open Date: December 2, 2024

Close Date: November 12, 2027

Status: Posted

CFDA Numbers: 93.853

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Career Transition Award for NINDS Intramural Clinician-Scientists (K22 Clinical Trial Required)

Deadline: November 12, 2027

Opportunity Number: PAR-25-216

Agency: National Institutes of Health

Open Date: December 2, 2024

Close Date: November 12, 2027

Status: Posted

CFDA Numbers: 93.853

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Innovative Screening Approaches and Therapies for Screenable Disorders in Newborns (R01 - Clinical Trial Optional)

Deadline: November 16, 2027

Opportunity Number: PAR-25-265

Agency: National Institutes of Health

Open Date: December 2, 2024

Close Date: November 16, 2027

Status: Posted

CFDA Numbers: 93.865

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Innovative Screening Approaches and Therapies for Screenable Disorders in Newborns (R21 - Clinical Trial Optional)

Deadline: November 16, 2027

Opportunity Number: PAR-25-266

Agency: National Institutes of Health

Open Date: December 2, 2024

Close Date: November 16, 2027

Status: Posted

CFDA Numbers: 93.865

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NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)

Deadline: November 13, 2026

Opportunity Number: PAR-25-270

Agency: National Institutes of Health

Open Date: December 2, 2024

Close Date: November 13, 2026

Status: Posted

CFDA Numbers: 93.213

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NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)

Deadline: November 13, 2026

Opportunity Number: PAR-25-269

Agency: National Institutes of Health

Open Date: December 2, 2024

Close Date: November 13, 2026

Status: Posted

CFDA Numbers: 93.213

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NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required)

Deadline: November 13, 2026

Opportunity Number: PAR-25-271

Agency: National Institutes of Health

Open Date: December 2, 2024

Close Date: November 13, 2026

Status: Posted

CFDA Numbers: 93.213

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