Synopsis

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This Notice of Funding Opportunity (NOFO) invites researchers to submit applications for support of new exploratory and developmental research projects that address critical needs for Down syndrome projects, as articulated in the INCLUDE Project objectives. For example, such projects could assess the feasibility of a novel area of investigation or a new experimental system that has the potential to enhance health-related research. Another example could include the unique and innovative use of an existing methodology to explore a new scientific area. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.
Response Date	Jun 15, 2028 12:00:00 AM EDT
Posting Date	May 12, 2026 12:00:00 AM EDT
Archive Date	Aug 14, 2028 12:00:00 AM EDT
Award Ceiling	200,000
Award Floor	N/a
Cost Sharing	No

Eligibility

Eligible Applicants

City or township governments, Public housing authorities/Indian housing authorities, Native American tribal governments (Federally recognized), Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Small businesses, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Public and State controlled institutions of higher education, Special district governments, State governments, Native American tribal organizations (other than Federally recognized tribal governments), Independent school districts, County governments, Others (see text field entitled "Additional Information on Eligibility" for clarification), For profit organizations other than small businesses

Additional Info on Eligibility:

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name	National Institutes of Health
Link to Additional Information:	N/a
Grantor Contact Information:	If you have difficulty accessing the full announcement electronically, please contact: GrantSolutions Help Desk Phone: 301-402-2541

CFDA Program(s)

• 93.121: Oral Diseases and Disorders Research
• 93.173: Research Related to Deafness and Communication Disorders
• 93.233: National Center on Sleep Disorders Research
• 93.310: Trans-NIH Research Support
• 93.351: Research Infrastructure Programs
• 93.395: Cancer Treatment Research
• 93.837: Cardiovascular Diseases Research
• 93.838: Lung Diseases Research
• 93.839: Blood Diseases and Resources Research
• 93.840: Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders
• 93.846: Arthritis, Musculoskeletal and Skin Diseases Research
• 93.855: Allergy and Infectious Diseases Research
• 93.865: Child Health and Human Development Extramural Research
• 93.866: Aging Research
• 93.867: Vision Research
• 93.879: Medical Library Assistance