Synopsis

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit Transformative Research Award applications to support individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research that has the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies related to Down syndrome. Applications are welcome in all topics relevant to Down syndrome-related research or its co-occurring conditions. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in research related to Down syndrome.
Response Date	Jun 15, 2028 12:00:00 AM EDT
Posting Date	May 12, 2026 12:00:00 AM EDT
Archive Date	Aug 14, 2028 12:00:00 AM EDT
Award Ceiling	500,000
Award Floor	N/a
Cost Sharing	No

Eligibility

Eligible Applicants

Small businesses, City or township governments, Native American tribal governments (Federally recognized), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Others (see text field entitled "Additional Information on Eligibility" for clarification), Special district governments, Public and State controlled institutions of higher education, Native American tribal organizations (other than Federally recognized tribal governments), County governments, Independent school districts, State governments, Public housing authorities/Indian housing authorities, Private institutions of higher education, For profit organizations other than small businesses

Additional Info on Eligibility:

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name	National Institutes of Health
Link to Additional Information:	N/a
Grantor Contact Information:	If you have difficulty accessing the full announcement electronically, please contact: GrantSolutions Help Desk Phone: 301-402-2541

CFDA Program(s)

• 93.121: Oral Diseases and Disorders Research
• 93.173: Research Related to Deafness and Communication Disorders
• 93.233: National Center on Sleep Disorders Research
• 93.242: Mental Health Research Grants
• 93.310: Trans-NIH Research Support
• 93.350: National Center for Advancing Translational Sciences
• 93.351: Research Infrastructure Programs
• 93.395: Cancer Treatment Research
• 93.837: Cardiovascular Diseases Research
• 93.838: Lung Diseases Research
• 93.839: Blood Diseases and Resources Research
• 93.840: Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders
• 93.846: Arthritis, Musculoskeletal and Skin Diseases Research
• 93.847: Diabetes, Digestive, and Kidney Diseases Extramural Research
• 93.855: Allergy and Infectious Diseases Research
• 93.865: Child Health and Human Development Extramural Research
• 93.866: Aging Research
• 93.867: Vision Research
• 93.879: Medical Library Assistance