Synopsis

The Engineering Biological and Biomedical Systems (EBBS) program expands our understanding of biological and physiological systems, and it helps improve human health. For U.S. leadership in biotechnology, the engineering of biology is required at every scale. Engineering is needed for sensing biomarkers to making proteins to restoring functions of the body. In EBBS, fundamental mechanistic insights are combined with experimental and computational techniques. This approach helps develop platforms, devices, organisms, tissues, and processes that bring new understanding and control of biological functions. EBBS supports studies of mechanisms that drive the behavior of microbial populations and cells, and of therapeutic cells and tissues. This includes discovering the underlying engineering principles that are needed to capture the responses of biological systems and bioreactors. It also includes the creation of novel biosensing platforms and new optical imaging and modulation strategies. Research that enables the design of biological systems to sense and respond to novel stimuli is welcome. Similarly, projects leading to insight into tissue changes or injury, and to systems that imitate or restore the functions of tissues or organs are encouraged. Projects that advance rehabilitation engineering through new theories and approaches are supported by the EBBS program. Fundamental engineering research driven by the needs of persons with disabilities is encouraged. The EBBS program expands what is possible in biomanufacturing; research may advance biotechnology and/or health. EBBS research must enable improved biological processes, create novel biomedical technologies, or achieve new understanding of physiological or pathological processes. EBBS does not support proposals with a main goal of drug design, drug delivery, or the development of animal models of disease. Using existing models for experimental testing and validation is acceptable. Projects that focus on testing and validating therapies are not supported. Clinical trials are not supported. Limited studies involving human volunteers may be supported if appropriate to the project objectives. Projects focused on commercialization are more appropriate for the NSF Directorate for Technology, Innovation, and Partnerships (TIP). Partnerships: To speed discovery and innovation, NSF partners with federal agencies, industry, international groups, and others. Current opportunities are at NSF ENG Partnerships.
Response Date
Posting Date	Apr 24, 2026 12:00:00 AM EDT
Archive Date
Award Ceiling	N/a
Award Floor	N/a
Cost Sharing	No

Eligibility

Eligible Applicants	Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"
Additional Info on Eligibility:	N/a

Additional Information

Agency Name	U.S. National Science Foundation
Link to Additional Information:	NSF Program Desccription PD-26-369Y
Grantor Contact Information:	If you have difficulty accessing the full announcement electronically, please contact: GrantSolutions Help Desk Phone: 703-292-4203

CFDA Program(s)

• 47.041: Engineering