Synopsis

The purpose of this notice of funding opportunity (NOFO) is to support the advancement of systems-level understanding of the link between infectious pathogens and inflammatory pathways that result in predisposition, onset and progression of chronic diseases. The NOFO will stimulate integration of clinical and patient data, large-scale omics datasets, advanced Artificial Intelligence (AI) and computational modeling to prevent, treat, and mitigate the combined impact of chronic diseases, inflammation, and infections.
Response Date	Feb 18, 2027 12:00:00 AM EST
Posting Date	Nov 04, 2026 12:00:00 AM EST
Archive Date	Apr 18, 2027 12:00:00 AM EDT
Award Ceiling	2,500,000
Award Floor	N/a
Cost Sharing	No

Eligibility

Eligible Applicants

Independent school districts, County governments, Native American tribal organizations (other than Federally recognized tribal governments), Special district governments, Public housing authorities/Indian housing authorities, Others (see text field entitled "Additional Information on Eligibility" for clarification), State governments, City or township governments, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Small businesses, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Native American tribal governments (Federally recognized), For profit organizations other than small businesses, Public and State controlled institutions of higher education

Additional Info on Eligibility:

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Additional Information

Agency Name	National Institutes of Health
Link to Additional Information:	N/a
Grantor Contact Information:	If you have difficulty accessing the full announcement electronically, please contact: GrantSolutions Help Desk Phone: 301-402-2541

CFDA Program(s)

• 93.121: Oral Diseases and Disorders Research
• 93.172: Human Genome Research
• 93.543: Vision Research - Research Projects
• 93.8AM: National Institute of Allergy and Infectious Diseases-Antimicrobial Resistance
• 93.8RP: National Institute of Allergy and Infectious Diseases- Research Projects
• 93.8TD: National Institute of Allergy and Infectious Diseases-Tickborne Diseases
• 93.ADR: NIH Office for Research on Women's Health - Office of Autoimmune Research
• 93.AGR: National Institute on Aging Research Projects
• 93.AR1: Arthritis, Musculoskeletal and Skin Diseases Research - Research Projects
• 93.DSS: NIH Office of Data Science Strategy (ODSS)
• 93.HL2: National Heart, Lung, and Blood Institute - Research Projects