Through this NOFO, IPT’s Invasive Species program aims to support projects that advance tangible improvements in invasive species prevention by utilizing existing research knowledge on invasive species risks and pathways to produce actionable outcomes that protect American agriculture from invasive species. For example, past and current research has built important pre-invasion knowledge of problematic pests, such as through horizon scanning and monitoring ex-patria sentinel trees. We invite proposals that build upon and directly link this type of invasive species scientific knowledge to make improvements in regulatory frameworks, policies, and actions that will decrease new arrivals and establishment of invasive pests. Projects should bridge the gap between current research knowledge and concrete actions that will improve how the U.S. prevents the introduction and establishment of new invasive species.